Restless Leg Syndrome Medication: A Comprehensive Guide for Effective Relief

Nov 19, 2023


As a leading authority in vascular medicine, Truffles Vein Specialists understands the impact of restless leg syndrome (RLS) on the lives of countless individuals. We are dedicated to providing top-notch care and effective treatment options for RLS. In this comprehensive guide, we will explore various restless leg syndrome medications and help you navigate your way towards finding long-awaited relief.

Understanding Restless Leg Syndrome

Restless leg syndrome, also known as Willis-Ekbom disease, is a neurological disorder characterized by an uncontrollable urge to move the legs, usually accompanied by uncomfortable sensations. This condition can significantly disrupt sleep and diminish overall quality of life.

Restless Leg Syndrome Medication Options

1. Dopaminergic Medications

Dopaminergic medications are often considered the first line of treatment for restless leg syndrome. These medications work by increasing dopamine levels in the brain, helping to regulate brain activity and reduce RLS symptoms.

Commonly prescribed dopaminergic medications include:

  • Ropinirole (Requip): This medication stimulates dopamine receptors in the brain and has been shown to effectively relieve RLS symptoms.
  • Pramipexole (Mirapex): Another dopamine agonist, pramipexole, has been found to significantly reduce the severity and frequency of RLS symptoms.

2. Gabapentin Enacarbil (Horizant)

Gabapentin enacarbil is an extended-release form of gabapentin, a medication commonly used to treat seizures and nerve pain. It has also been approved for the treatment of moderate-to-severe primary restless leg syndrome.

3. Benzodiazepines

Benzodiazepines are a class of drugs that act as sedatives, muscle relaxants, and anticonvulsants. While not specifically approved for RLS, they may be prescribed to help relieve symptoms, especially if sleep disruption is a primary concern. Examples of benzodiazepines include diazepam and clonazepam.

4. Opioids

Opioid medications are potent analgesics that may be utilized in severe cases of RLS when other treatments have failed. It's important to note that opioids carry potential risks and should only be prescribed under close medical supervision.

Lifestyle Changes and Home Remedies

In addition to medication options, incorporating certain lifestyle changes and home remedies can help manage restless leg syndrome. Consider the following:

1. Regular Exercise

Engaging in regular exercise, such as walking, swimming, or cycling, can alleviate RLS symptoms and promote better sleep patterns.

2. Establishing a Sleep Routine

Creating a consistent sleep routine by going to bed and waking up at the same time each day can regulate sleep, reducing the frequency and intensity of RLS episodes.

3. Warm Baths and Massages

Taking warm baths before bed and receiving massages can provide temporary relief by relaxing the muscles and soothing discomfort.

4. Avoiding Triggers

Avoiding triggers such as caffeine, nicotine, and alcohol, especially in the evening, can help minimize RLS symptoms. Additionally, maintaining a healthy diet and managing stress levels can contribute to overall well-being.


At Truffles Vein Specialists, we understand the challenges posed by restless leg syndrome. By offering a comprehensive range of effective medications and emphasizing lifestyle modifications, we aim to improve the lives of individuals suffering from RLS. Consult with our experienced doctors in the field of vascular medicine to find the best restless leg syndrome medication and treatment plan tailored to your unique needs. Let us help you find relief and regain control over your sleep and overall well-being. Contact us at today!